By Cornelius Kennedy Cain; American Chemical Society. Division of Medicinal Chemistry
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Additional resources for Annual reports in medicinal chemistry, 1965
3, 863 (1965). A. Ribbentrop and W. , B,863 (1965). A. M. Monro. R. M. Quinton and T. I. Wrigley, J. Med. , 6, 255 (1963). N. J. Giarman and G. Pepeu, Brit. J. , 9, 123 (1964). Z. P. Horovitz. A. R. Furgiuele, L. J. Brannick, 3. C. Burke and B. N. Craver, Nature, 44. 45. 46. 47 * 48. 62. 62a. 63. 64. 6566. 67. 68. 69 * 70. - 71. 72 73. 74. 75. 76. 77. 78 * 79. 80. 81. 82. 83. 84. 85. 86. 87 88. 88a. 88b. 88c. 886. 8989a. 89b. - 148. B, a, N, z, (1962). w, 200, 369 (19631. 1. S. Mapp. R. Dykyj, C.
Many agents produce swelling without a t t e n d a n t increase i n pain s e n s i t i v i t y . A f a c t o r o r f a c t o r s which a r e r e l e a s e d by c e r t a i n agents which produce inflammation may be r e l a t e d t o hyperesthesi This f a c t o r i s n o t s e r o t o n i n o r bradykinin. Winter and F l a t a k e r$3 using a v a r i e t y of hyperesthesia-producing agents, have shown t h a t indomethacin and t h e narcotic-antagonists can reduce hyperesthesia a t doses which do not a f f e c t swelling and which do n o t a f f e c t t h e pain threshold of uninflamed t i s s u e .
H e n d r i c k s e and P. M. S h e r m a n , Lancet 1965, p. 737. (31) H. 0. M a r s h , J. Am. Med. A s s o c . &, 797 (1965). (32) H. H. B e r m a n , 0. Noe and F. 5, 430 (1964). (33) C. Darienzo, D i s e a s e s Nervous S y s t e m 27, 189 (1965). (34) E. W. McChesney, W . F. Banks, J r . , G. A. P o r t m a n a n d A . V . R . Grain, F e d e r a t i o n P r o c . (2), 418 (1966). (35) C. K . C a i n and A. P. Roszkowski in”Psychopharmacologica1 Agents:‘ Vol. I, M. Gordon, E d . , A c a d e m i c Press, New York, N.