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Additional resources for Advances in lipid research. . V. 21
Studies using cultured cells suggest that the metabolism of plasma LDL in vivo can, in part, be attributed to adsorptive endocytosis via the highaffinity LDL receptor specific for apoB H found in parenchymal and connective tissue cells. By this mechanism apoB of LDL transports cholesterol to specifically targeted tissues (those having LDL receptors). Other potential mechanisms for LDL and apoB H disposal exist which include the scavenger-cell pathway of macrophages and fluid endocytosis. In rats, metabolic studies may be complicated by the presence of apoB L in LDL.
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